I started with a new, front wheeldrive Subaru in '71 or '72. Good set up for a young guy with no fear.
Since then, owned several Chevy Suburbans and Jeep Cherokees.
Recent years I own(ed) Ford Rangers, extended cab, with cap (topper). I had the aluminum cap made with side windows, with locks. I operate out the side window (my side) and only open back to place dead critters inside. I also got a 'rack' on my cap to haul our canoe, but it's also hauled molding, lumber, pipes and ladders.
Fur season, I have rubber bed mat, then I place tarp down, then I place fitted cardboard down, all to protect bed. At the rear I have newpaper and burlap to place dead critters. Burlap and newspaper gathers blood and water.
I like the pickup best for my needs and comes in handy for haul'n throughout the year. Even with a small pickup with cap, you have plenty of room for 'stuff' while traveling. Wife and I done this many times.